Griseofulvin
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What is Griseofulvin and Why is it used in the Treatment of Fungal Infections?

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What is Griseofulvin and what is it used to treat?

Griseofulvin has earned a spot on the World Health Organization’s List of Essential Medicines and has been approved by the U.S. Food and Drug Administration since 1962 under the drug class of antifungal agents. This medicine is utilized for the treatment of a number of skin infections such as ringworm, athletes’ foot, and other nail and skin fungi that do not respond to creams or lotions.

How is Griseofulvin used in the Treatment of Fungal Infections?

Griseofulvin works to interfere with fungal mitosis by preventing fungal cells from dividing and multiplying, ultimately causing the infection to die off. By clearing the infections and fungus, symptoms such as itching, red, peeling, scaly skin, and discolored nails will subside.

Is Griseofulvin an Over-The-Counter Medicine?

Though griseofulvin increases steroid hormone levels, it is considered an antibiotic that requires a prescription from a licensed medical professional before it can be dispensed at pharmacies. Once obtained, this oral antibiotic can be taken as a tablet, capsule, or liquid suspension. It is usually taken once a day but maybe prescribed for up to two to four times per day depending on age, the condition being treat, and other medical conditions.

How Long Does it Take for Griseofulvin to Work?

Symptoms may noticeably improve in a few days, but it usually takes about two to four weeks for skin infections and four to six weeks for hair and scalp infections to be completely gone. Even if symptoms quickly recover, use this medicine for the full prescribed length of time and as directed by your doctor or directions on your prescription label.

What are the Most Common Side Effects of Griseofulvin?

Along with needed effects, this medicine may cause unwanted side effects and though not all side effects may occur, it is important to look out for the following reactions:

Common Side Effects:

  • Blistering, peeling, or loosening of the skin
  • Nausea, vomiting, upset stomach
  • Diarrhea or loose stool
  • Headache
  • Tiredness
  • Thirst
  • Sleep problems (insomnia)
  • Dizziness

Serious Side Effects:

  • Fever
  • Sore throat
  • Skin rash
  • Mouth soreness or irritation
  • Yellowing of skin or whites of eyes
  • Numbness, tingling, or weakness of hands or feet
  • Large hive-like swelling
  • Chest pain
  • Shortness of breath

Griseofulvin should not be taken if you are pregnant or breastfeeding, especially in the first trimester as birth defects may be incurred. Griseofulvin also can diminish the strength of birth control pills, so talk to your doctor about alternative birth control options to prevent pregnancy. This medication is not approved for use for anyone under the age of 2 years old.

This is not a complete list of side effects and others may occur, call your doctor to discuss any potential side effects that may be experienced while utilizing this medication. Call 911 if your symptoms feel life-threatening or you feel like you are having a medical emergency.

How can Chem Service Help Drug Manufacturers Test their Products for the Quality and Amount of Griseofulvin Used?

Chem Service provides griseofulvin analytical standards for Pharmaceutical quality control using chromatography. Our Certified Reference Standards are for laboratory use only, the creation of both qualitative and quantitative analysis methods, and calibration requirements, and quality control testing for food and beverage products. Contact Chem Service for more information on Griseofulvin’s analytical standards. Our products may not be used as drugs, cosmetics, agricultural or pesticide products, food additives, or as household chemicals.

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